Tsunade vs Genkai
VS
Time shifts. Parallel universe. Whatever.
Point is, Genkai (before giving half her power to Yusuke) finds herself having to fight Tsunade.
Scenario 1:
Genkai vs Tsunade in the Open Valley where The Three Sannin fought against each other. An all-out brawl with any available powers. No holding back, and to the death.
Scenario 2.
The two elderly women duke it out in a Dark Tournament Style Ring. No room for summons, and if caught out of the ring for 10 seconds, you lose.