Xenoblade
Originally announced during during E3 2009 as Monado: Beginning of the World for the Nintendo Wii, it's true name has been revealed to be Xenoblade and it appears to be a continuation of the great Xenosaga series (being developed by Monolith Soft, created by Tetsuya Takahashi, the 'Xeno' in the title, and the 'x4' in the website all suggest as much).
Not too much information has been revealed so far but if it follows the stylistic approach of Xenogears and the Xenosaga Trilogy then it's set to be a truly great game.
http://en.wikipedia.org/wiki/Xenoblade
http://www.nintendo.co.jp/wii/sx4j/index.html