Originally posted by Juntai
Spear of Destiny is actually a theory in the comics. It harms him, but no one is sure if it could kill him, or if he can be killed at all.
In PC era, Superman was shown a glipse of the future. In that future, Superman killed Spectre with the Spear.
In FC, Cain also was able to kill Spectre, but he never did. He enslaved him already.
Though, I am sure you know that already