LOST ODYSSEY.
Honestly, it is my favorite game on the console, hands-down. It is a freaking Final Fantasy in everything but name, but has a much darker tone than most FFs have. It's brilliant, in my opinion. It is also one of a small handful of games that everyone I work with played - since we all have very varied tastes in games, that is a big deal.
Dragon Age is worth playing but I'm assuming you've played it already since you said "no Bioware".
Fable II is worth playing. It's very quick, though. I got halfway through the story in about 6-7 hours of play. For just plain messing around, though, it's hilariously fun and entertaining. I think I had a husband in one town, a wife in another, and a girlfriend in a third. Awesome.
Oblivion bored the hell out of me, I got through about three hours of play and never touched it again.
Blue Dragon is pretty good. Not perfect, but still a decent game. I don't think I ever finished it though, because I got Lost Odyssey. I've heard good things about Eternal Sonata but I never picked it up myself. Same with Tales of Vesperia and Star Ocean.
Definitely avoid Infinite Undiscovery and Last Remnant, though. Tried them out, they're no good.