Donna with all her latest upgrades (post-resurrection strength boost) and Lasso of Persuasion.
Vs
Kara Zor-El
Who comes out on top?
KON
KontonHomo Magi
Donna still doesn't have the strength feats Kara has. She has also shown to have a will strong enough to destroy Wonder Girl with her own lasso, so I'm not sure if ditzy Donna is going to fair much better in that regard.