Deadpool takes this without too much difficulty.
The power of syngergy - when the sum is greater than the individual parts. Pretty basic concept really.
As soon as the fight starts, Deadpool TPs behind Cyke and kills him. Then its DP vs Wolvie/Wraith, and I don't see what Wraith is going to do.
If its Deadpool fighting as himself (rather than being controlled by Stryker), than its even more of a no-brainer since he showed greater skill as Wade Wilson.