Janet's relationship is *messed up*. Remember, the way she got married was when he had a multiple personality problem, she married the fake personality knowing it was fake, then held him to it when Hank recovered.
Carol also had the "mind-drained so her memories didn't feel like hers" thing going on. Her story's weirder due to more external things than Janet's, but it's still pretty odd.
I wouldn't call them sluts by any means, but their personal lives are still train wrecks.
Sue, not so much, but Reed does occasionally cause major relationship friction.
tkitna
Lois swears and was a smoker.
Aside from the smoking, that's barely anything. She has a great career and personal fulfillment.
Lois has a few minor normal problems, and in the smoking one got over it. Compared to her pluses, I think she wins.