If that was the case, the only one with any real "exotic" powers is Colossus. It might take time to figure out what "turns it on".
If you're Wolverine, you may pop your claws out all the time, but its not that big a deal. You may be over whelmed by all the smells and improved hearing though.
With Spiderman, Parker was fine once he got his powers. The trouble would be webslinging, but jumping really far shouldn't be a problem. Its a natural extension of some thing we already do. Using a slingshot with web, pretty doable IMO
Toad is just nasty. Having to wake up as that would be horrible.
With all that said, I doubt power user difficulty is what is going to make or break the race.