This is not necessarily true because of Selene's advanced senses she could locate Wesker first and could use the glave grenades to catch Wesker with an explosion which effectively neutralizes him. Or Wesker could spot Selene first and put lead in her with his double desert eagles. If it devolves into a fist fight while Wesker is faster Selene seems to me to be stronger and has a more effective healing factor which could give her the win if he slips up. And depending upon who wins between Bourne and Hit-Girl one could almost help to secure the win with their partner against the other team because neither Selene or Wesker showed enough of a healing factor to lead me to believe that they could be completely immune to pistol or machine gun shots to the end.