The Borg Cube versus a Yautja Star Destroyer
Imagine it: An Imperial class Star Destroyer occupied entirely by Yautja. No Star Wars personnel at all, just Yautja.
The Destroyer encounters a Borg Cube.
The Borg deliver their famous opening spiel.
The Borg begin to teleport drones onto the Destroyer to begin assimilation.
The Yautjas have all of their Predator weapons, as do the Borg.
Can the Predators kill off the parasitic Borg or do the Yautja become assimilated?