XanatosForever
Steward of RP
The X are parasitic life-form native to SR388. They reproduce asexually and rapidly in their natural environment, going from perhaps four or five individual parasites to hundreds, at least. They seek out hosts to inhabit and absorb their forms and knowledge from within. The Metroids are the main predators and natural enemies of the X, capable of absorbing the parasites life-force en masse to keep the species in check. In Metroid Fusion, an X infection almost kills Samus Aran, and drastically alters her physical form. A vaccine developed from the cell culture of an infant metroid, the baby Metroid, in fact, saves her life, killing off the infection. The few specimens left attached to her old Power Suit were shipped to a research station orbiting SR388, and the X were able to manifest a copy of Samus with the full complement of her suit functions, and after breaking free, the X proceeded to overrun the station. Only the timely arrival and intervention of Samus prevented the X from spreading across the galaxy. I'd add more but at this point I'm dipping into the main plot of Metroid Fusion.
I think what makes them so deadly is their tendency to absorb theirs hosts completely, essentially taking their form and all the knowledge they pertain. If the X were to, say, absorb a Cerebrate or something, they could wreak havoc amongst the Zerg, not to mention all the absorbed "Xerg" that would come into being. I'm not sure what they would do about creep, but again, these are just my basic opinion and reasoning as to why I think the Zerg would have trouble fighting the X.