Thanos vs Red Skull

Thanos gets the reality gem, and Red Skull has an artificial Cosmic Cube.

Who wins?

I'd give Thanos the edge to his knowledge of both the Gem and the cube, whilst Skull only has knowledge of the cube

The Red Skull should definitely be the stronger of the two given the circumstances, but I could definitely see Thanos out thinking and out smarting The Red Skull here...

Thanos wins...

Red Skull beats Thanos, nothing the titan can really do without resorting to selfbfr.

I don't know how powerful the reality gem is by itself...

So I give it to the red skull.

Gems won't even matter, Thanos will effortlessly outwit Red Skull of the cube

Red Skull + Cosmic cube.