So they take the same path as the A-Wave which means they are going to go against Galactus at some point along with the various Empire's the A-Wave was fighting.
Plus the bigger the threat more powerful being generally get involved like what happened in the Thanos Imperative. I say they don't make it.
So we are assuming the wave originates at the fault? And makes its way towards Earth?
Earth's in big trouble.
Odin/Zeus ect Pantheon would have to protect the Earth. With Galactus and his huge destructive ability + all heralds. Guardians of the Galaxy and the Shiar and Kree warriors getting in the way. Trying to stop the wave moving forward from deepest space.
If they get through Earth has options like summoning Cthon with the Darkhold. A Sorceror Supreme. All superheroes and villains united, Inhumans, Doom with time travel, Rulk can absorb the overpowered, Reed with Celestial Kill gun the list goes on and on.