Blade vs Buffy.

They have 21 vampires to eliminate
7 true blood types
7 twilight types
7 underworld types

Winner is determined by most vampires killed. They have 1 hour. Location your neighborhood

Blade

Yeah, Blade. Buffy could drop them also (particularly with the scythe from season 7) but it would take more than an hour. Blade's better equipped and far more aggressive.