Depends on what Lobo you're talking about, the one that broke his hand on Darkseid's face could clone all he wanted to, and still lose, and the one that was tossed several miles by Despero would lose, the version of Lobo that Lou killed would also lose and I'm adding even if he cloned.
Those Lobo's never had the Durability of Superman that could possibly withstand the nuclear or what I like to call the Banner Bomb strike, that could wipe out Wendigo, FinFang Foom, Bi-Beast, Arm'Cheddon and everything else we saw to dust.
Even Lobo from REBELS wouldn't be up to the task. he and his duplicates would be pushed away when we consider that what happened in the Dark Dimension was technically not the Hulks limit.
I need to be fair of course though, if Lobo/s under these conditions fought the Hulk in a populated area, he/they would wipe him out with ease.
And here comes the shit storm, just remember that everything I said was my opinion. I'm actually happy that we will likely never see the Hulk at those levels again, because the implications of what he could do makes for poor comics.