Originally posted by ZampanóFrom Destiny's Way:
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"That's not what the Empire would have done, Commander. What the Empire would have done was build a super-colossal Yuuzhan Vong-killing battle machine. They would have called it the Nova Colossus or the Galaxy Destructor or the Nostril of Palpatine or something equally grandiose. They would have spent billions of credits, employed thousands of contractors and subcontractors, and equipped it with the latest in death-dealing technology. And you know what would have happened? It wouldn't have worked. They'd forget to bolt down a metal plate over an access hatch leading to the main reactors, or some other mistake, and a hotshot enemy pilot would drop a bomb down there and blow the whole thing up. Now that's what the Empire would have done."
If Empire is aware of Yuuzhan Vong's existence, then they have no chance. Their main weapon was deception and destabilization. If it was Empire instead of Republic, the first thing they would do is infiltrate and disable Death Star. And they would start open war only after they are sure, that Empire is crippled enough to be defeated. But they would still not win because of hidden technologies inside Maw. Indestructible ship armor and smaller version of Death Star is a guarantied win. And if we take Palpatine into equation, who knows what other super weapons he would invent during the war. Not to mention that they can't kill him, he would resurrect as much as he wanted.
The only reason the New Republic had so much trouble beating them was because they gave the Vong so much time and rope, refusing to commit until the Vong had serious momentum.
If the NR had responded promptly and in full force, they would've won much sooner and more solidly with much less damage.
Pretty much any time the galaxy is unified and at least semi-militarized will beat the Yuuzhan Vong invasion.