Originally posted by Q99
Orochimaru seems like the type that you can't count on poisons working on.
That said, I see no reason for why Orochimaru would be able to resist Mayuri's poison. Also, Mayuri displayed rather amazing speed when he fought and kept up with Uryū.
Not really different from a body flicker- Orochimaru and the other sannin were able to leap around the boss summons like little blurs.
Oro did give Sasuke high general poison resistance, it's unlikely he'd not do so to himself.
One additional poison resistance tactic he has- body mass. Turn into a massive 8-headed snake. Any poison'll be incredibly diluted, aside from any other biological resistances.