Ock has taken Spider-Man, Hulk, and Iron Man.
Lizard has no ranged weapons to nullify the doctor's reach advantage and nothing he can do once caught by one or more tentacles.
Ock has demonstrated the speed to deflect bullets from a machine gun, and Lizard lacks any of Spider-man's subtlety; it's not realistic to think he'll get caught by Lizard if he's squared off against him in a formal fight.
Only chance I see for Connors is if Octopus is surprised by the Lizard's strength level enough for him to be thrown off-balance, or, if by some miracle, Lizard proves strong enough to break one of those mechanical arms. Given that, again, Ock's tentacles have proven strong enough to hold the Hulk (they'd been re-designed and replaced with more durable alloys since Ock's original debut) that doesn't seem likely.
Ock wins 8/10.
When he fought the Hulk, he had the adamantium harness. That's not his standard equipment.
Parker broke his tentacles more than once (even recently) and Lizard is three times stronger than him.
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Originally posted by CrazyDave
I totaly agree with that.
Originally posted by StiltmanFTW
Ock has a carbonadium tank protecting his body.