Predator vs. Spider-Man
Spiderman finds himself waking up in the middle of a jungle with no idea what's going on except for the fact that something or someone is stalking/hunting him. Spiderman gets no weapons, just him and his suit. The Predator gets his standard weapons and gear, except for the self destruct mechanism. Also the Predator does not know of Spiderman's powers, but assumes that he is capable of defending himself. They both start out about a mile away from each other.
Garfield's Spider-Man vs Wolf from Aliens vs. Predator: Requiem
Who ends up coming out alive?