Originally posted by sCOURGE_0Dean no. Depends on what season Sam.
Don't Sam and Dean have some magic or something? Otherwise Leon would kill them in a direct fight
But I don't know enough about Leon. But being Resident Evil I'd say he probably take it. Sam and Dean while fight things super human they usually get their butts handed to them. Though to be fair these days its usually Demons and Angels they have to contend with..