Monoliths (Space Oddessey) vs... umm... everything else? Including Doc Manhattan?
So it is the daddy of Sci-Fi superpowers, the Monoliths from 2001: A Space Oddessey.
This fight seems sort of unfair from the very moment you say the words Monoliths, partly because the Monoliths are both where you see and also not, they part exist in reality when they choose to and don't at the same time. Some sort of 'technological singularity' that we are not meant to be able to understand fully.
I suppose, the only way to make this fight fair would be set them against absolutely everything else in Sci-Fi, and this would be valid because the Monoliths don't particularly care much for humans, or any Earth dwelling lifeform/creation for the matter. And to be honest, they don't seem to particularly care for anything at all in regard to life and creation apart from that which is their own, they only thing they do seem to care about are the lifeforms they created on Europa which is specifically indigenous to Space Oddessey.
And they will obviously defend them to the extreme no matter what comes along.
So, drawing an entire armarda of Hollywoods Sci-Fi heroes, villians, anti-heroes and any other device or creation... this is the big one.
(PS. I don't think it would be a good idea to just say "the Universe would blow up"... let's just assume that the Monoliths and their competitors would like to keep the Universe intact).