Nurgle's diseases were said to have made a complete mockery of Moration's legendary resistance to disease and pain.
This is the guy who drinks lethal poison as a refreshing beverage and breathes it 24/7 for fun. He even grew up on a planet completely enveloped in poison and disease.
Unless there is some specific feat of Vergil resisting hardcore diseases I am inclined to think the destroyer plague adds a new victim to the list.