Between the two of them, they could just keep ki nuking the area.
That clash they had just before the Seven Capital Cities of Heaven story blew apart the top of the building they were on. Spider-Oct and Ben are fast, but not fast enough to dodge two walking bombs.
If they fight conventionally... Here's the thing. Even if the Spider-twins are quicker, it's not enough where Danny can't roll with their punches, or react to their attacks. Using boxing terms,If Spider-Oct and Ben could move like featherweight boxers who could punch like middleweights, Iron Fist is about as quick as a super featherweight to lightweight, but can hit like a light heavyweight.
In other words, he only needs to land one or two good attacks, and he doesn't even need to score direct hits. Even a miss creates a shockwave strong enough to knock Luke Cage off his feet, when he wasn't even the target, and that was before he learned to project ki..