Lobo/Hercules vs Thor/Orion - Split.
Lobo/Orion vs Thor/Hercules - Split.
I'm assuming Lobo cannot create clones but it's a high end portrayal, not one that is a lot more vulnerable.
Anyways, they are all pretty much equal. The only advantage I can think of is that Lobo isn't really a team player and isn't as skilled as the other three so in a hand to hand fight that might give other combinations the advantage if you want to examine it from a more technical standpoint.