Cloverfield monster took bunker penetrating bombs and what is hinted to either be a MOAB or small nuke so nothing Stark has stands any chance. Nothing Spiderman can do would slow it down. Only hope would be to get Wolverine on its back and get him to keep hacking away until it's dead and that depends on whether he can generate enough force to get the blades into the monster anyway which is unlikely given that armour piercing rounds and bunker buster bombs couldn't do it.
Clovie wins