Lizard is slightly above classic 10 ton parker I thought. And yeah, being a skilled martial artist will make this a good fight. Skill plays a big role in comics but in real life, most martial artists would get floored by prison inmates. Pure unadulterated violence and brutality wins most fights more often than taking some after school karate class. I think the Lizard would maul the crap out of most street level characters.
Lizard wins via speedblitz+claws,fangs=massive lacerations and blood loss as opposed to blunt force trauma on an armored creature with a healing factor.