Depends on the level of the Juggernaut. I don't see how a normal human is going to do much damage against Cain before he was reduced in power. Even with Longshot helping out, the X-Men were pressed to even slow him down for a while. Skill shouldn't mean a thing. If it's Cain that fought King Hyperion when his durability was reduced, there may be a chance.
I'm not entirely sure what the writers are trying to do with Cain these days without making him vulnerable enough to get his knee caps broken by even guys on Hyperion's level? There was a time that such an attack would have bounced off of him. Marvel wrote him to be physically unbeatable when he was first made.
So this really depends on the level that Cain is on.