Deadpool vs. Superman
Takes place in Metropolis. Superman is not completely invulnerable anymore (he can be killed from enough force and without kryptonite). Deadpool is just Deadpool, and he has all of his powers and weapons. I'm not going to bother asking about the comic versions fighting the movie versions, because comic versions are OP.
Two rounds:
1. Comic vs. Comic
2. Movie vs. Movie
Who wins and why?