when has Joker ever given Batman a decent fight? The only times i can recall him getting good shots on Batman is after Batman has been poisoned, shot, blown up, or otherwise hampered by injury.
that said, if these guys don't have weapons and they don't simply hold him down and crush his skull, he can take them due to having an insane pain threshold. And like KingD said, he'd probably phuck one of them up so badly that the other would run away.
Joker is a slippery fighter, he hasn't gotten the upper hand on Batman directly but he's so tricky that he can get the upper hand with something up his sleeve...literally. and if he can get the drop on Batman like that he'd take at least two goons out with acid flower or joy buzzer before the rest run