Beniboybling
Worst Member
It does make sense, because the Force or rather the living Force is generated by living tissue. And to use the Force is to channel that energy through your living body.
This is taken from the Revenge of the Sith novelisation:
And you rage and scream and reach through the Force to crush the shadow who has destroyed you, but you are so far less now than what you were, you are more than half machine, you are like a painter gone blind, a composer gone deaf, you can remember where the power was but the power you can touch is only a memory, and so with all your world-destroying fury it is only droids around you that implode, and equipment, and the table on which you were strapped shatters, and in the end, you cannot touch the shadow.
As this is from George Lucas himself, which I believe makes it G-Canon:
However, after all of his limbs were severed, and he was extremely burned on Mustafar, he lost much of his Force potential. As Darth Vader, Skywalker was believed to have had roughly 80% of the strength of the Emperor. Had he sustained none of his injuries on Mustafar, he would have been twice as powerful.
And no, Vader is not unique. Lumiya, a cyborg and pupil of Vader's was unable to master Sith battle meditation, despite her expertise on its principles, which she attributed to her prostheses. General Grievous was pumped with Sifo-Dyas' blood, but it failed to give him Force sensitivity.
Indeed what doesn't make sense is that if the brain and blood of a Jedi were transplanted into a cyborg body such as Grievous', it would be able to use the Force.
However, if we are to understand midichlorians as mitichondria as you suggest, then I don't believe cybernetics would have an effect on one's midichlorian count, as like with mitichondria, its not the number in your entire body that's important, but in any given cell. Given that, Vader's connection to the Force would remain intact, but he'd still have difficulty channeling that Force energy, because his cybernetics would disrupt the flow.
A surmountable obstacle, but an obstacle nonetheless. And I think I'd say the same of physical infirmity.