Solid Snake CQC'd Gray Fox, who was able to stop a 300 ton MG from stomping him, MGS4 Raiden who tap danced using Gekko's a bludgeons and restrained Vamp, who was able to fight Raiden in melee, or that he's a clone of Big Boss, same Big Boss who stopped Peace Walker from stomping him, Peace Walker being 25 meters tall
As for speed, there's the whole "Grey Fox being able to deflect machine gun fire and Snake being able to CQC him" and "needing to climb 100 underground floors in 60 seconds", outjumping supersonic missiles and a few others I'm prolly missing out on
Even if we ignored all that above (well we shouldn't but what's the harm, anything for the fight to look kinda fair), what difference does it make?
Snake still has a shit ton of weapons (even Metal Gear handguns are BS powerful, but I'll stop right there) such as grenades, grenade launchers, RPG's and a fragging railgun
Even his tranquilizers are nothing to be scoffed at, being able to KO even Gecko's