Given how often Otto tags Spidey, he should tear up Sabertooth. Otto's damage soak is also irrationally high for being what he is.
I don't mean to discredit Sabertooth here. He's a beast in his own right, and either of these guys could win. In fact, on paper, Sabertooth probably does win. But Ock's collective body of work is higher than most realize. I'd give him the slightest of majorities, so long as we count KO's and other incapacitations.