yeah, if its just h2h and Drake can't use his sword then its definitely a harder fight for team 1 but Nomak is a savage h2h fighter and Drake completely overpowered Blade once he changed into his perfect form so they can still win this thing. Markus was handled pretty easily by Celine once she got her unspecified power up so its no out of the realm of possibility that a powerhouse like demonic Drake could do so as well. VH Drac would be a problem due to massive regen but if team 1 could incapacitate him long enough to kill Markus quickly enough then they have a good chance.
Markus was only beaten by Selene when she got am amp from his dad, the most powerful of the immortals. He even agreed as he was dying that he could have easily stopped Hybrid Markus, but he refused to hurt his son. So that made her stronger than him, especially since she was like 600+ years old and vampires grow in strength as they age. So she was beyond him at that point.
Nothing Drake did was beyond what Markus or Selene have done. He's not as strong as either of them.
And they wouldn't be able to incapacitate Dracula, especially if he goes full Man-Bat.