Thor/Loki vs. Spiderman/Lizard
No Mjolnir for Thor, no staff/scepter for Loki. Loki still gets his near unlimited supply of daggers (as seen in his fight against the frost giants) and he can give his brother daggers as needed.
Spiderman and Lizard from ASM. Spidey gets unlimited webbing. Fight to the death. Fight takes place in New York times square.
All other inherent powers/abilities are still active.
On a physical level they can make the gods work for it though, they just wont be able to hurt them. Lizard should be able to definitely contend with Loki until he gets koed or so many magical daggers through him he passes out to regen. His speed will help him last but he can at least keep Loki busy as Thor will one shot him.
Spidey is the best bet for Thor and should last much longer than lizard due to way they fight, Lizard would go straight in thinking he is stronger and more durable of the two and probably get his skull fisted. Spidey should be strong enough and those webs of his mixed with the crazy spins and speed he can achieve allow him to sling Thor's 654 lb Asgardian ass like a Lacrosse ball quite a damn distance and with some force. But it wont matter, he cant hurt him.
Thor and Loki 10/10 due to Thor being able to just stand there and let them hit him and they would die of old age. They can beat his ass all day but eventually he will tag em and theyre done for.
Didnt think you were golem. He will be tough to tag but its not impossible. It's a numbers and endurance game. I can't make the claim for Loki but Thor can literally take a nap and I don't see them being able to actually injure him. Saying he cant tag someone doese t justify a win though I believe Thor could use the environment as well.