Luke Cage(Netflix) vs Ajax(Deadpool)

Ajax believes Jessica Jones has mutant power so he kidnappes her but before he get to torture her Luke shows up to free her all he has to do is defeat Ajax

Francis via KO. His pain tolerance will wear off a few hits to Cages's body lot enough for him to register he can't damage him, and Cage will never land a hit and Francis can probably KO him via a few good hits to the head. Unless Francis breaks his fist of something, in which case it's probably a stalemate worse case scenario for Ajax

Nah, Ajax is fast but he's not unhittable. And unless Ajax has a shotgun lying around I don't see him generating enough force to KO Luke. He'll probably break his hands hitting Luke and he won't even realize it because he feels no pain.

Luke Cage

Cage. Pretty easily, probably.