Best Hand-to-Hand fighters in SW?

Squirrel Girl fite me.

Not even sure the power of PIS would save Squirrel Girl from the God Emperor. 🙂

She would befriend him and defeat his heart. SG > Galactus, Doom and Thanos in canon.

You just implied that even SG being above Galactus, Thanos, Doom, the Living Tribunal, Eternity, and Infinity combined would put her above God Emperor Doom. Shame on you. 🙂

The magic of friendship is the greatest force in the universe, **** you.

Universe? God Emperor Doom > the Multiverse, b!tch. 🙂