Depends whether you mean ingrained knowledge that most could access in an archive, or secret routes and planets that aren't known to the wider galaxy.
Yoda, Windu and Kenobi knew planets like Rodia and Glee Anselm so well they could identify different cities, which is impressive, and Kenobi knew sector coordinates for almost every world. Given that they also had access to secret hyperspace routes in the deep core (such as the ones that Sidious have to Dooku for the Battle of Coruscant) I'd say they have the best knowledge of the galaxy in the Clone Wars era, not Madame Jocasta.