Well, since even nullification is out of the question, it means the character would essentially have to battle Fury long enough to significantly deplete his energy stores.
With that in mind, it took an extended battle between peak Fury and 616 MJJ --wherein they were constantly dimension-hopping, and going warp-for-warp with one another-- just to finally tax Fury's energy-reserves enough for him to be killed by conventional means(and that was after he figured out a way to kill Jaspers himself.)
Ergo, the being in question would have to be no less that equal to 616 MJJ to even have a shot at beating Fury. Imo.
No worries. 😉
It is out of the question, because Fury already survived the nullification of its entire native universe(designate 238):
...And that was before Fury was at it's peak. Before it had absorbed certain components that made it significantly more powerful--powerful enough to contend with, and eventually kill, 616 MJJ in fact.
