I don't believe that Parker would need prep to defeat Piotr. Piotr obviously has the durability advantage, and the strength, but Parker bring speed, agility, precognitive powers, and a percentage of strength to the table. Could enough uninterruptible hits hurt Piotr? This should really be the question here. I for one believe that it would be possible. He did defeat Firelord with enough punches, even though the fight was PIS. However how much PIS was involved?
1. Firelord could have ended the battle with a large enough blast which would have killed Spiderman.
2. His flight speed should have also given him a huge advantage, but Piotr doesn't use blast, and can not fly.
Those two things made the battle PIS, but the blows that put Firelord down and out wasn't PIS. Piotr is likely more durable to physical attacks than Firelord, because Parker would most likely break his hands punching him directly, but what would happen if he repeatedly webbed Piotr up, and slammed him into the concrete environment. I believe that he could eventually win this way. So what I'm basically saying is that it wouldn't be physically impossible for Spiderman to beat the hell out of the much slower, less agile, one trick pony that Piotr actually is.
Colossus wins 9/10 if he manages to land a blow.
Spiderman wins 8/10 if he manages to evade.