Deadpool vs Blade
No morals, to the death. Setting is a multi-story research facility. Both are after a drug that they need for whatever fill-in-the-blank reason you like. Movie versions of both, feats shown by all versions are acceptable. For clarification, I mean Wade Wilson feats from Wolverine as well as what's seen in Deadpool, but not that horrid little trope that Stryker crafted at the end of Wolverine.