I was going to balance out his higher speed and agility with her good grappling in martial arts skill. Maybe he is as strong, but when she punches a giant man made of a high-powered steel, and stuns him and knocks him back dozens of feet and doesn't hurt her hands, I think she is going to break beast apart as soon as she starts to lay hands on him. I believe she can take anything he can dish out for quite a while.
It was pretty strongly implied that Colossus was not going all out against Angel Dust.
I think if Colossus fought Beast, Piotr would struggle to lay a hand on him, but I don't see Beast being able to do lasting damage. Just like Angel Dust was unable to do, up until she started choking him. But if you put Beast in a similar position to how Angel Dust had him, I think Hank would also possibly be able to choke him out. And if Hank used his car tossing strength to hit Colossus in the nuts, I definitely think he'd feel it.
And the example is still not ideal, because Angel Dust does not have the same level of durability as Colossus. We visibly see that he is bulletproof (we see nothing of the sort for her), and he was not KO'd by Negasonic whereas she was.
And yeah, Wade did cause her pain with a headbutt. Now he did no lasting damage, but if he can cause her pain, Beast can do way worse. Beast strength >>>>> Wade strength.