Speaking as someone who regularly emphasizes the value of numbers... of course he can handle this. There's only four of them, and they aren't that strong.
Darth Krayt was in a similar position, except four Imperial Knights > four Inquisitors. And that took, like, two seconds.
Darth Sidious is stronger than Darth Krayt. And heck, the three of the B-team he killed are also stronger than the Inquisitors solidly.
Plus, you gave him stormtroopers! Which *do* help reduce the effect of numbers advantage (see: The Conclave at Kessel, where some stormies helped save Darth Vader from multiple Jedi Masters).