Originally posted by XSUPREMEXSKILLZ
By One Above All, I'm referring to the Celestial, my bad.And as Galan noted, Thanos' omniscience and what not would prevent him from being caught off guard. Thanos' only way to lose is if he gets cocky.
Right, but my main point here is that he COULD lose. He would have to get cocky or be caught off guard, but he could lose like that. So there are ways that someone like Jiren could pull a W.
I don't see Zeno pulling one in any scenario though, simply because I couldn't see him trying something like that, let alone succeeding.