Oh no, there are rational reasons for taking drugs. I'm very pro war on drugs, but there are a few I'd consider taking.
Aderall/ritalin: As a college student this would be my nuclear option if I find myself failing to meet expectations. Some questionable side and long-term effects must reserve it as a last-resort option.
Steroids (Testosterone, IGF1, Tren, pro-hormones) : As a body-builder, I pride myself on being natural, however after the age of 50 when my natural hormone levels drop I'd most likely compensate with steroids. Used responsibly they can be a viable option to keep yourself in good health.
Cocaine: Very unlikely I ever will due to its short-term "high" at the cost of serious long-term effects. If I needed to go a serious time without sleep maybe, but aderall might be better for all-nighters.
Mushrooms/LSD: There is no rationality behind these hallucinogenic drugs other than I'm curious for the experience.