Using this method of thought:
1. What is the best thing that can happen if action is taken
2. What is the worst thing that can happen if action is taken
3. What is the best thing that can happen if action isn't taken
4. What is the worst thing that can happen if action isn't taken
The jedi sacrificing himself for civilians in the Vader comic vs B-team attacking Palpatine's civilian staff is different.
RotS:
What's the best thing that can happen if B-team attacks civilians to get to Palpatine?
The Chancellor could be the sith lord they've been searching for and he's put out of power hence preventing the galaxy from a totalitarian leader.
What's the worst thing that can happen if B-team attacks civilians to get to Palpatine?
Palpatine may not be a sith-lord at all (thanks dumbass Anakin) and the jedi just committed political suicide by overthrowing a democratically elected ruler in addition to attacking innocent civilians. This would be the straw that broke the Camel's back when you consider the current dislike towards the Jedi by much of the galaxy already.
What's the best thing that can happen if B-team doesn't attack civilians to get to Palpatine?
Nobody gets hurt and things resume as usual.
What's the worst thing that can happen if B-team doesn't attack civilians to get to Palpatine?
They just wait a bit longer to collect more evidence and public support to find the right opening to "arrest" him without attacking civilians.
Comic
What's the best thing that could happen if the jedi sacrificed civilians to continue fighting Vader?
He might be able to defeat Vader and put an end to his reign of terror on the galaxy. At the very least he could wound him and make it more difficult.
What's the worst thing that could happen if the jedi sacrificed civilians to continue fighting Vader?
He could lose the battle and still allow Vader to spread terror across the galaxy at the cost of the sacrificed civilians who would've died anyway had he not sacrificed them.
What's the best thing that could happen if the jedi didn't sacrifice cvilians to continue fighting Vader?
Vader might have some respect for the jedi and possibly spare them; though every jedi knows this is unlikely.
What's the worst thing that could happen if the jedi didn't sacrifice civilians to continue fighting Vader?
Vader would've done what he did anyway in the comic and more across the galaxy.
Two very different scenarios with different risks and stakes involved.