Gao wrecks in Round 1. Honestly don't see un-enhanced Slade being able to put her down. She got repeatedly smacked around by people like Jessica Jones (who clobbered her with a large piece of piping at one stage), and even took an Iron Fist at one point, and didn't even have a scratch on her when we see her for the final time.
Round 2 is closer. Mirakuru Slade is pretty damn durable, and will be extremely hard to put down too. If Slade can power past her TK and get close, he might be able to try and snap her neck or something.
Though it does also depend on gear. If Slade has his sidearm, he could try shooting her, assuming he can get a shot off before she uses her tk on him. And that's assuming guns will work. Bakuto, another Finger of the Hand, completely ignored 3 gunshots to the chest. However, the power levels and abilities of the different Fingers seemed to vary, so I wouldn't assume anything based on Bakuto.