Hard to judge. The team has too many numbers. Any of the Spidermen should be able to beat Tony's civil war suit solo (except maybe Holland with how much he jobs), but War Machine was the same suit from all the other movies and that thing nearly as good as Tony's suits.
I'm also not sure how Black Panthers suit would hold up to the combined blunt trauma of the Spider-Men but it's made out of Vibranium and Caps shield took a hit from the hammer like a champ, so they may not be able to hurt him. They could just web him up though. He doesn't have the strength to break out of that.
Falcon, Hawkeye, and Widow are all fodder here, they'd go down. Winter Soldier, and Cap wouldn't be much of a problem either. Just web them all up and knock them out. Ant Man should also go down the same way Holland beat him (I'm assuming he's Giant Man here; Ant Man would be pretty useless against Spidey). Scarlet Witch is dangerous if she can turn one of them of she can TK catch them, but a web ball from Maguire should KO her. She's a glass cannon.
If they play it smart and are pretty liberal with the webbing, the Spider-Men should take this. War Machine and Scarlet Witch may swing this the other way though.