Dunno, they'll be losses, but I still feel retail will go on. While the convenience of Amazon can't be ignored, you do a few clicks and 48hrs later a box arrives at your house, people still like to touch, feel and see in person certain items. Maybe not their laundry detergent bottle, but something like a television or decorative item.
I remember when eBooks first started out and it was expected that the bookstore would go the way of the dodo in 'X' amount of years because why go buy a book when you can just download it onto your Kindle or other device in a matter of seconds. But people like the feel and smell of books when reading; they like browsing around in an actual bookstore, so the bookstores remain, though arguably scaled back some.
I can relate to BF's story, Toys R Us going under hits a soft spot in my heart. I have very fond memories of going as a child and the unrestrained exciting when pulling into the parking lot and then taking my own children decades later and seeing them glow with the same joy.