If Apoc gets his shields up, I don’t see what anybody can do to him. His offensive feats weren’t over the top on attacks, but he telekinetically used city rubble to construct a pyramid with high tech wiring and design (from rubble) that would transfer his conscious into Xavier. He can prob shield the others so Phoenix can attack safely.
This largely depends on Superman, to be honest, and his speed. Because the mutant team has more than enough hax abilities to win (from teleportation, to matter manipulation, telepathy, telekinesis, shields etc.).
It would be interesting to compare Apocalypse's or David's reactions to Superman's. Apocalypse took around 15 seconds to respond to Quicksilver, from Quicksilver's perspective, which translates to a tiny fraction of a second in real time. And David caught a bunch of machine gun rounds in his hand while his back was turned. Granted, it's still not clear whether that was enhanced speed/reactions, or some reality warp that moved the bullets to his hand. Either way, he was able to react to it.