At the end of the day Spidey's villains are simply more powerful, but this is still a good fight as they are the two most prolific rogue galleries of all time, w/ X-men's as a distant 2nd/3rd.
The other interesting point is that many of Batman's villains are more powerful than Batman, whereas many of Spider-Man's are less powerful than Spidey. I mean Batman would but a sever hurting on Vulture